Using multi-tracer inference to move beyond single-catchment ecohydrology

CKD classification: time to move beyond KDOQI.

The number of patients with ESRD is increasing worldwide. Despite recent advances in our understanding of the uremic state and improvements in the science and technology of renal replacement therapy, the morbidity and mortality of these patients is unacceptably high: More than 20% per year. Moreover, the health care cost of treating ESRD exceeds $17 billion annually in the United States alone.1...

Algorithms for MDC-Based Multi-Locus Phylogeny Inference: Beyond Rooted Binary Gene Trees on Single Alleles

One of the criteria for inferring a species tree from a collection of gene trees, when gene tree incongruence is assumed to be due to incomplete lineage sorting (ILS), is Minimize Deep Coalescence (MDC). Exact algorithms for inferring the species tree from rooted, binary trees under MDC were recently introduced. Nevertheless, in phylogenetic analyses of biological data sets, estimated gene tree...

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

Physiological variability manifests itself via differences in physiological function between individuals of the same species, and has crucial implications in disease progression and treatment. Despite its importance, physiological variability has traditionally been ignored in experimental and computational investigations due to averaging over samples from multiple individuals. Recently, modelli...

Foucault's Move beyond the Theoretical

Spatial scale dependence of ecohydrologically mediated water balance partitioning: A synthesis framework for catchment ecohydrology

[1] The difficulties in predicting whole catchment water balance from observations at patch scales motivate a search for theories that can account for the complexity of interactions in catchments. In this paper we suggest that the spatial patterns of vegetation may offer a lens through which to investigate scale dependence of hydrology within catchments. Vegetation patterns are attractive becau...